About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to addressing the underlying cause of severe diseases by upregulating protein expression with RNA-based medicines. Using the company’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Stoke’s first compound, STK-001 is in clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. Dravet syndrome is one of many diseases caused by a haploinsufficiency, in which a loss of ~50% of normal protein levels leads to disease. Stoke is pursuing the development of STK-002 for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. Stoke’s initial focus is haploinsufficiencies and diseases of the central nervous system and the eye, although proof of concept has been demonstrated in other organs, tissues, and systems, supporting the company’s belief in the broad potential for its proprietary approach. Stoke is headquartered in Bedford, Massachusetts with offices in Cambridge, Massachusetts.

Position Purpose:

The Bioanalytical, DMPK and Biomarker Development team is seeking an enthusiastic, collaborative and experience Bioanalytical Scientist to join their team. This position will report to our Associate Director of DMPK and is located in our lab facility at 45 and 47 Wiggins Avenue, Bedford, MA.

Key Responsibilities:

• 
  Developing high-quality assays to quantitate oligonucleotides in biological matrices to understand the pharmacokinetics (PK) and metabolism of drug candidates.
• Responsible for sample analysis to support PK/PD and other non-clinical studies, interpret results and report data to support pipeline.
• Partner with and support Pharmacology and Discovery Biology teams.
• Conduct oligonucleotide stability profiling and metabolite identification studies.
• Work with CRO laboratories to transfer, qualify/validate bioanalytical assays, and support assay implementation.
• Write technical reports as needed.
• Present results at cross-functional team and lab meetings.
• Maintain accurate documentation of experiments in ELN.
• Help maintain the bioanalytical lab and keep the instruments running properly.

Required Skills & Experience:

• At Scientist level: Bachelor’s degree with 10+ years of experience, or Master’s degree with 8+ years of post-graduate experience, or Ph.D. with a minimum of 2 years of relevant experience working in industry or academia.
• Proven experience with LC-MS platforms such as QqQ and HRMS (Sciex/Thermo) for quantitation of drug molecules.
• Experience using immunoassay techniques like ELISA, MSD, Western blotting etc. will be a plus.
• Strong knowledge of bioanalytical principles is required. Experience in metabolism aspect of oligonucleotides is desirable.
• Good understanding of bioanalytical assay development, validation, and implementation.
• Excellent problem-solving skills and ability to work as a team player in a dynamic environment.
• Excellent communication and presentation skills required.
• Proficient in standard Microsoft Office tools: Word, Excel, GraphPad and PowerPoint.
• Strong attention to detail and organizations skills.
• Prior drug development experience in nucleic acids-based therapeutics will be plus.
• Basic understanding of GLP with ICH and FDA Guidance is a plus.

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Culture & Values:

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led DIB Committee underscores Stoke’s values and the importance of DIB to who we are and what we do.

To protect the health and well-being of our team, company policy requires that all employees and all new hires be fully vaccinated against COVID-19. By applying, you are confirming that, if hired, you can satisfy this express condition of employment. We will make reasonable accommodations available as may be required by applicable law. We will continue to evaluate our practices as we move forward.

Location(s):

Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in our Bedford, MA location.

Travel:

This position will require approximately 0-5% travel.

Benefits & Compensation:

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/ or follow the company on Twitter at @StokeTx.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.