Job description

Supporting its proprietary nucleic acid-based technology platforms, my client is seeking a Principal Scientist, Formulation at its Hunstville, AL, facility to play an integral role in developing novel nucleic acid delivery formulations. My client is a pre-revenue, integrated biopharmaceutical company focused on developing a portfolio of innovative treatments for cancer and infectious diseases using its DNA-mediated gene transfer technologies.

Our lead product is GEN-1, a DNA-mediated immunotherapy for the localized treatment of ovarian cancer. Our newest program in development is a novel plasmid DNA-based investigational vaccine for preventing or treating infections from a broad range of infectious agents including the coronavirus disease using our PLACCINE DNA vaccine technology platform.

The successful candidate will:

• Produce and characterize novel nucleic acid formulations, based on companys proprietary synthetic delivery systems, including DNA or mRNA RNA nanoparticles or nanocomplexes.

• Conduct analytical characterization of the formulations understanding the interaction between nucleic acid and the delivery agents, and defining factors driving an optimal interaction, formulation reproducibility, stability, and transfection activity in vitro and in vivo.

• Perform standard analytical methods for formulation characterization including dynamic light scattering, spectroscopic analysis, gel electrophoresis, particle sizing, and zeta potential. Experience with transmission electron microscopy and atomic force microscopy will be seen preferably.

• Conduct experiments to evaluate cell transfection activity and stability characteristics of the formulations to advance scientific understanding of the formulated systems and achieving respective project objectives.

• Demonstrate the ability to work independently to develop formulations, optimize and troubleshoot the process.

• Be extremely detail-oriented and place high value in documentation of work for communication to supervisor, other team members and sound development of documentation practices.

• Effectively communicate with technical and business-oriented audiences within the company through presentations and written reports.

Job Type: Full-time

Pay: $100,000.00 - $150,000.00 per year

Benefits:

• 401(k)
• 401(k) matching
• Dental insurance
• Flexible schedule
• Health insurance
• Paid time off
• Vision insurance

Schedule:

• Monday to Friday

Supplemental pay types:

• Bonus pay

Ability to commute/relocate:

• Huntsville, AL 35801: Reliably commute or willing to relocate with an employer-provided relocation package (Preferred)

Application Question(s):

• Do you have experience within nucleic acid delivery formulation?

Do you have Hands-on experience in DNA or RNA delivery formulation?

Do you understand the interaction between nucleic acid and the delivery agents, and defining factors driving an optimal interaction, formulation reproducibility, stability, and transfection activity in vitro and in vivo.

Education:

• Doctorate (Preferred)

Work Location: One location

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